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Since the amines in Advantra Z® are not as lipophilic as those in ma huang/ephedra, they do not readily cross the blood/brain barrier. In fact, the unique amine composition in Advantra Z® prefers retention in the periphery rather than passage into the brain. Additionally, research shows that Advantra Z® stimulates beta-3 cell receptors with minimal impact on alpha 1,2 and beta 1,2 receptors, which means that Advantra Z® increases the metabolic rate without affecting heart rate or blood pressure unlike ma huang/ephedra.